DNA methylation enzyme inhibitor RG108 suppresses the radioresistance of esophageal cancer

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DNA methylation enzyme inhibitor RG108 suppresses the radioresistance of esophageal cancer

Esophageal cancer (EC) is the eighth most common highly aggressive cancer worldwide. The purpose of this study was to investigate the effect of the DNA methyltransferase inhibitor RG108 on the radiosensitivity of EC cells. MTT and clonogenic assays were performed to assess the effect of RG108 on the proliferation and radiosensitivity of Eca‑109 and TE‑1 human EC cells. The cell cycle progressio...

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P-128: The Effect of DNA Methyl Transferase1 Inhibitor (RG108) on DNA Methylation Pattern of Cloned Mouse Embryos

Background: In somatic cell nuclear transfer (SCNT) method of cloning, transferred nucleus should be dedifferentiated from differentiated state to embryonic state. Molecular analysis showed that the reprogramming in the transferred nucleus was incomplete and cloned embryos have epigenetic abnormalities such as high DNA methylations levels. Since methylation in pre-implantation embryos has a cri...

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The Impression of Histone Modification and DNA Methylation in Gastric Cancer Development: Molecular Mechanism Approach

The epigenetic alterations like histone modifications , DNA methylation and others remarkable categories  including nucleosome remodeling and RNA mediated targeting have been strongly investigated  recently .In this way , beside the notable importance of DNA methylation ,the histone modifications are the most important issues in the  tumorogenesis and cancer progression. Moreover...

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PGC7 suppresses TET3 for protecting DNA methylation

Ten-eleven translocation (TET) family enzymes convert 5-methylcytosine to 5-hydroxylmethylcytosine. However, the molecular mechanism that regulates this biological process is not clear. Here, we show the evidence that PGC7 (also known as Dppa3 or Stella) interacts with TET2 and TET3 both in vitro and in vivo to suppress the enzymatic activity of TET2 and TET3. Moreover, lacking PGC7 induces the...

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Anti-tumoral effect of the non-nucleoside DNMT inhibitor RG108 in human prostate cancer cells.

BACKGROUND Current therapeutic strategies for advanced prostate cancer (PCa) are largely ineffective. Because aberrant DNA methylation associated with inappropriate gene-silencing is a common feature of PCa, DNA methylation inhibitors might constitute an alternative therapy. In this study we aimed to evaluate the anti-cancer properties of RG108, a novel non-nucleoside inhibitor of DNA methyltra...

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ژورنال

عنوان ژورنال: Oncology Reports

سال: 2018

ISSN: 1021-335X,1791-2431

DOI: 10.3892/or.2018.6210